Diagnostic Impact of Cerebrospinal Fluid Biomarker (Pre-)Analytical Variability in Alzheimer’s Disease
نویسندگان
چکیده
منابع مشابه
Diagnostic Impact of Cerebrospinal Fluid Biomarker (Pre-)Analytical Variability in Alzheimer’s Disease
Intra- and inter-laboratory variability of cerebrospinal fluid (CSF) biomarker analyses remains an important issue. We investigated the clinical-diagnostic impact of CSF biomarker concentration shifts in mild cognitive impairment (MCI) and autopsy-confirmed Alzheimer's disease (AD) dementia patients. MCI patients (n = 85), autopsy-confirmed AD dementia patients (n = 72), and cognitively healthy...
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BACKGROUND Analyses of cerebrospinal fluid (CSF) biomarkers (β-amyloid protein, total tau protein, and hyperphosphorylated tau protein) are part of the diagnostic criteria of Alzheimer disease. Different preanalytical sample procedures contribute to variability of CSF biomarker concentrations, hampering between-laboratory comparisons. The aim of this study was to explore the influence of fracti...
متن کاملPreanalytical variables and Alzheimer disease biomarker concentrations in cerebrospinal fluid.
Cerebrospinal fluid (CSF) -amyloid (A 1–42) is one of the key biological forms of -amyloid protein in brain tissue that inversely reflects brain amyloid burden with reduced concentrations in Alzheimer disease (AD) (1 ). Reductions in CSF A 1–42 have been shown to occur years before symptom onset (2 ) and to have good positive predictive value for progression from mild cognitive impairment to cl...
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During the last decade, the epidemiology of WNV in humans has changed in the southern regions of Europe, with high incidence of West Nile fever (WNF) cases, but also of West Nile neuroinvasive disease (WNND). The lack of human vaccine or specific treatment against WNV infection imparts a pressing need to characterize indicators associated with neurological involvement. By its intimacy with cent...
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BACKGROUND To identify meningioma-specific proteins, cerebrospinal fluid (CSF) from 4 patients with a meningioma and 4 patients with a non-brain tumorous lesion were analyzed. MATERIAL/METHODS Two-dimensional electrophoresis and electrospray quadrupole time-of-flight tandem mass spectrometry analyses revealed 10 unique spots, containing 11 independent proteins (spot #2 and #4 each contained 2...
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ژورنال
عنوان ژورنال: Journal of Alzheimer's Disease
سال: 2016
ISSN: 1387-2877,1875-8908
DOI: 10.3233/jad-150953